Journal: Journal of Translational Medicine
Article Title: Construction of a prostate adenocarcinoma molecular classification: integrating spatial transcriptomics with retrospective cohort validation
doi: 10.1186/s12967-025-06661-6
Figure Lengend Snippet: Immunohistochemical (IHC) staining of the marker genes of malignant cell differentiation-based PRAD classification (MDPC) and the prognostic prediction value of MDPC in overall survival (OS) and progression free survival (PFS). A The analysis flow of the IHC staining of the PRAD patients in a retrospective cohort was shown. B The IHC staining images of DPP4, MSMB, NHP2, NVL, COL1A1, and MYLK were exhibited. C , D Patients with COL1A1 + MYLK + MDPC were found to harbor the worst prognosis of OS and PFS through Kaplan–Meier (K-M) survival analysis. E , F COL1A1 + MYLK + MDPC served as a risk factor of OS (hazard ration (HR) = 20.72, P-value = 0.0018) and PFS (HR = 117.00, P-value = 0.0036) in PRAD. MDPC malignant cell differentiation-based PRAD classification, OS overall survival, PFS progression free survival
Article Snippet: The IHC staining images of DPP4, MSMB, NHP2, NVL, COL1A1, and MYLK were obtained from the human protein atlas (HPA) database ( https://www.proteinatlas.org/ ).
Techniques: Immunohistochemical staining, Immunohistochemistry, Marker, Cell Differentiation